Manchester City have now won only once in 11 games in all competitions.
A stoppage-time finish from Rayan Cherki earned Olympique Lyonnais a dramatic 2-2 draw with Manchester United in the first leg of their Europa League quarter-final.
Three late goals from Amad Diallo dragged a below-par Manchester United to an unlikely 3-1 comeback victory over bottom side Southampton.
A round-up of Saturday's action in the English Premier League.
Forward Rasmus Hojlund scored twice to allow Manchester United to come back from a goal down and get a 2-1 win at six-times Czech champions Viktoria Plzen in the Europa League on Thursday.
Manchester United languish 14th in the standings on 19 points, their worst placing to end a calendar year since they were 15th in 1989.
The win leaves United in 15th place in the Europa League standings on six points from four games.
A summary of Thursday's action in the Premier League.
Moises Caicedo's blistering second-half strike cancelled out a Bruno Fernandes penalty as Chelsea salvaged a 1-1 draw with Manchester United on Sunday.
IMAGES from the English Premier League matches played on Wednesday.
The favourites to replace Erik ten Hag, who was sacked as Manchester United manager on Monday.
Barcelona twice threw away the lead to draw 3-3 at Levante on Tuesday in a potentially fatal blow to their chances of winning the La Liga title.
Manchester City squandered a three-goal lead to draw 3-3 with Feyenoord in the Champions League on Tuesday.
Images from Wednesday's Champions League matches, between Real Madrid and Paris St Germain, and Manchester City and Sporting CP
Images from the UEFA Champions League group matches played on Tuesday night
Europa League kings Sevilla breezed past Manchester United into the semi-finals of their favourite competition as Youssef En Nesyri scored twice